abstract：:BACKGROUND The imbalance between bone resorption and formation is the basic mechanism underlying osteoporosis in the elderly. Osteogenesis is the differentiation of human mesenchymal stem cells (hMSCs) into osteoblasts. Sirtuin6 (SIRT6) regulates various biological functions, including differentiation. Transient recep...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Xiao F,Zhou Y,Liu Y,Xie M,Guo G

更新日期：2019-11-08 00:00:00

abstract：:BACKGROUND The fifth and sixth cervical vertebrae (C5-C6) represent the high-risk segment requiring surgical correction in cervical spondylosis. Anterior cervical discectomy and fusion (ACDF) of C5-C6 includes an intervertebral fusion cage to maintain foraminal height and is combined with anterior plate fixation. The ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wang J,Qian Z,Ren L

更新日期：2019-11-07 00:00:00

abstract：:BACKGROUND Numerous studies have evaluated the relationship between RNASEL gene polymorphisms (rs486907 G>A and rs627928 T>G) and the risk of cancer. However, many of the results have been controversial. To explore the role of RNASEL gene polymorphisms in prostate cancer, we carried out the present meta-analysis. MATE...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Xia J,Sun R

更新日期：2019-11-05 00:00:00

abstract：:Osteoporosis is an important health problem worldwide. Siwu decoction (SWD) and its modification have a good clinical effect on osteoporosis. However, the molecular mechanism of SWD on osteoporosis has not been thoroughly explained. A systematic pharmacological methodology was utilized to predict the active compounds ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Bao T,Yang K,Long Z,Zeng L,Li Y

更新日期：2019-10-31 00:00:00

abstract：:BACKGROUND Our previous study found a novel fluid combination with better resuscitation effects under hypotensive condition at the early stage of uncontrolled hemorrhagic shock (UHS). However, the optimal recovery concentration of hypertonic saline in this fluid combination remains unknown. This experiment aimed to ex...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Xu L,Kang F,Hu W,Liu X

更新日期：2019-10-30 00:00:00

abstract：:BACKGROUND We evaluated the utility of three-dimensional transperineal ultrasonography in detecting occult stress urinary incontinence in women undergoing anterior pelvic floor reconstruction surgery for severe cystocele. MATERIAL AND METHODS We enrolled 207 women with stage III-IV cystocele without urinary stress inc...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yin Y,Xia Z,Feng X,Luan M,Qin M

更新日期：2019-10-28 00:00:00

abstract：:BACKGROUND Er-Miao-San (EMS) is used in traditional Chinese medicine. This study aimed to investigate the effect of different elution fractions of EMS on acute inflammation induced by carrageenan in the rat paw and the possible mechanisms of action. MATERIAL AND METHODS Different aqueous fractions of EMS added to an A...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Dai X,Ding M,Zhang W,Xuan Z,Liang J,Yang D,Zhang Q,Su B,Zhu H,Jia X

更新日期：2019-10-23 00:00:00

abstract：:BACKGROUND Laryngeal cancer is one of the most common malignant tumors of the head and neck. Natural compounds in traditional Chinese medicine provide many valuable potential compounds for tumor chemotherapy. Esculetin, a coumarin derivative from several herbs, inhibits proliferation of many types of cancer cells, but...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang G,Xu Y,Zhou HF

更新日期：2019-10-20 00:00:00

abstract：:BACKGROUND The aim of this study was to determine the relationship between the expression of CD35 and CD64 from white blood cells (neutrophil, monocytes, and lymphocytes) and acute infectious diseases in children. MATERIAL AND METHODS The blood samples were collected from 104 children with infections (42 viral infecti...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Lu L,Jin X,Zhang Q

更新日期：2019-10-15 00:00:00

abstract：:BACKGROUND Endothelial progenitor cells (EPCs) play an important role in therapeutic angiogenesis. Besides, resveratrol (RSV) exerts many pharmacological functions in regulation of cell function. Furthermore, microRNAs (miRNAs) have been considered to be of great significance in biological process. In this study, we a...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Lu Z,Wang S,Zhu X,Yuan X,Zhan Y,Li Y,Wang W

更新日期：2019-10-13 00:00:00

abstract：:BACKGROUND This study aimed to investigate the inhibitory effect of imidazole on colon cancer cell proliferation and understand the mechanism involved. MATERIAL AND METHODS MTT assay and flow cytometry using Hoechst 33258 staining were used to assess cell proliferation and morphology, respectively. Changes in protein ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Long Y,Wang D

更新日期：2019-10-10 00:00:00

abstract：:BACKGROUND The aim of this study was to explore the impact of Ras homolog C/Rho-associated coiled-protein kinase (Rho/ROCK) signaling pathways intervention on biological characteristics of the human multiple myeloma cell lines RPMI-8226 and U266 cells, and to investigate the expression of RhoC, ROCK1, and ROCK2 in RPM...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Feng X,Zhang L,Nie S,Zhuang L,Wang W,Huang J,Yan X,Meng F

更新日期：2019-10-10 00:00:00

abstract：:BACKGROUND This study aimed to investigate the role of miRNA-339-5p in pancreatic cancer cell invasion and migration. MATERIAL AND METHODS The differences between exosomal miRNAs of PANC02 and PANC02-H7 were studied by microarray analysis. We measured miRNA-339-5p expression in different groups; differences in cell in...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yu Z,Zhao S,Wang L,Wang J,Zhou J

更新日期：2019-10-07 00:00:00

abstract：:BACKGROUND Type 2 diabetes impairs the healing process and induces apoptosis of fibroblasts, which are thought to be involved in this process. We investigated the possible mechanisms involved in AGEs-induced apoptosis of human dermal fibroblasts. MATERIAL AND METHODS We examined the expression of apoptosis-related pro...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Dai J,Chen H,Chai Y

更新日期：2019-10-06 00:00:00

abstract：:BACKGROUND Serine hydroxymethyltransferase (SHMT) is the enzyme that catalyzes the reversible conversion of serine to glycine and tetrahydrofolate-bound one-carbon unit. Upregulation of SHMT2 has been observed in a variety of cancers, but the expression profile and clinical value of SHMT2 in gastric cancer (GC) are st...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Shi H,Fang X,Li Y,Zhang Y

更新日期：2019-10-03 00:00:00

abstract：:BACKGROUND Acute myeloid leukemia (AML) is associated with a high relapse rate and poor prognosis. This study aimed to use weighted gene coexpression network analysis (WGCNA) of gene coexpression networks to identify candidate prognostic biomarker genes in patients with AML and to investigate the expression of these g...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Ye C,Ma S,Xia B,Zheng C

更新日期：2019-10-02 00:00:00

abstract：:BACKGROUND Laparoscopic cholecystectomy (LC) is regarded as the criterion standard for gallstone therapy, but post-cholecystectomy syndrome (PCS) is a common complication. This study aimed to analyze and identify differences in gut microbiome in PCS patients. MATERIAL AND METHODS This study involved 8 PCS patients (RS...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Kang Z,Lu M,Jiang M,Zhou D,Huang H

更新日期：2019-09-29 00:00:00

abstract：:BACKGROUND Colorectal cancer (CRC) has become a heavy health burden around the world, accounting for about 10% of newly diagnosed cancer cases. In the present study, we aimed to establish the miRNA-based prediction signature to assess the prognosis of CRC patients. MATERIAL AND METHODS A total of 451 CRC patients' exp...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Qian J,Zeng L,Jiang X,Zhang Z,Luo X

更新日期：2019-09-27 00:00:00

abstract：:BACKGROUND The present study assessed and compared the diagnostic accuracy of elastography (acoustic radiation force impulse, ARFI) with that of Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA⁺-M2BP) for estimating the stage of hepatic fibrosis in chronic liver disease patients. MATERIAL AND METHODS...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Chen CC,Hsu HT,Chen YL,Chen RC,Wu WP,Chou CT

更新日期：2019-09-24 00:00:00

abstract：:BACKGROUND The relationship between clopidogrel-resistance (CR) and polymorphism located in genes encoding clopidogrel metabolism-related enzymes has not been fully explored. Thus far, few studies on CR-associated polymorphism have been conducted in the Chinese population. The purpose of this study was to identify CYP...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Su Q,Li J,Tang Z,Yang S,Xing G,Liu T,Peng H

更新日期：2019-09-23 00:00:00

abstract：:BACKGROUND Interferon alpha (IFNalpha) exerts its anti-proliferative effect on many human cancers. Among the 13 subtypes of human IFNalpha, IFNalpha-1 subtype has 2 variants, named IFNalpha-1a and IFNalpha-1b, that differ from each other in only 1 amino acid, at residue 114. However, the mechanism by which IFNalpha-1a...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Xin XL,Zhang R,Yuan XM,Liu L

更新日期：2019-09-22 00:00:00

abstract：:BACKGROUND Higher fetal hemoglobin (HbF) levels can ameliorate the clinical severity of ß-thalassemia. The use of integrative strategies to combine results from gene microarray expression profiling, experimental evidence, and bioinformatics helps reveal functional long noncoding RNAs (lncRNAs) in ß-thalassemia and HbF...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Jia W,Jia S,Chen P,He Y

更新日期：2019-09-21 00:00:00

abstract：:Excessive drinking of alcohol is becoming a worldwide problem, and people have recognized that there exists a close relationship between chronic kidney disease (CKD) and alcohol consumption. However, there are many inconsistencies between experimental and clinical studies on alcohol consumption and kidney damage. The ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Fan Z,Yun J,Yu S,Yang Q,Song L

更新日期：2019-09-20 00:00:00

abstract：:BACKGROUND Oxidative stress in myocardial ischemia results in cardiomyocyte apoptosis. The expression of microRNA-141-3p (miR-141-3p) and the 105 kD toll-like receptor protein (TLR), RP105, have been identified in cardiomyocytes in vitro. This study aimed to investigate the effects of hypoxia in H9c2 rat cardiomyoblas...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Qin Q,Cui L,Zhou Z,Zhang Z,Wang Y,Zhou C

更新日期：2019-09-18 00:00:00

abstract：:BACKGROUND We studied the effect of APOBEC3G on persistent human papillomavirus (HPV) infection and the correlation between APOBEC3G polymorphism and HPV persistent infection and cervical disease progression in Uygur women in China. MATERIAL AND METHODS From January 2015 to December 2017, we enrolled 529 Uygur ethnic ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Sui S,Chen H,Han L,Wang L,Niyazi M,Zhu K

更新日期：2019-09-17 00:00:00

abstract：:BACKGROUND Clear cell sarcoma (CCS) of soft tissue, or malignant melanoma of soft parts, is a rare disease. We aimed to identify prognostic factors linked to patient survival in CCS by analyzing demographic and clinical features using the Surveillance, Epidemiology, and End Results (SEER) database. This study aimed to...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li AB,Jiang BJ,Wang HH,Yang YS,Zhang XB,Lan GH,Shu WB

更新日期：2019-09-15 00:00:00

abstract：:BACKGROUND Liver cancer is one of the most common malignancies around the world and one of the major causes of cancer related mortality. The objective of this study was to evaluate the anticancer effect of the natural compound psilostachyin-A on 5-fluorouracil-resistant human liver carcinoma cells and its effects on a...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu J,Liu Y,Liu Y,Huang L,Wang G,Wang J,Xu X,Shi C,Huang J

更新日期：2019-09-07 00:00:00

abstract：:BACKGROUND In previous studies, higher expression of PREX1 (PtdIns (3,4,5)P3-dependent Rac exchanger 1) has been detected in some subsets of breast cancer, and activation of PREX1 has been associated with tumor progression in vivo. However, an association between PREX1 and breast cancer prognosis has not been examined...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhong Y,Zhang J,Zhou Y,Mao F,Lin Y,Xu Y,Guan J,Shen S,Pan B,Wang C,Peng L,Huang X,Li Y,Cao X,Sun Q

更新日期：2019-09-01 00:00:00

abstract：:BACKGROUND The role of KIF18A in tumorigenesis and tumor development has been well studied in several cancers, but not in prostate cancer. In this study, we investigated the potential prognostic utility of KIF18A and its role in prostate cancer progression. MATERIAL AND METHODS We collected prostate cancer and paracan...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang H,Shen T,Zhang Z,Li Y,Pan Z

更新日期：2019-08-27 00:00:00

abstract：:The Fig 4C and 4D are the same, but the author showed them as two parallel groups. Reference: Cardioprotective Effect of Isosorbide Dinitrate Postconditioning Against Rat Myocardial Ischemia-Reperfusion Injury In Vivo Xinwen Zhao, Mengjuan Wang, Mei Li, Na Wu, Dalin Song Med Sci Monit 2019;25: 1629-1636 10.12659/MSM.9...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhao X,Wang M,Li M,Wu N,Song D

更新日期：2019-08-26 00:00:00

abstract：:The anterior transpedicular screws (ATPS) fixation is a valuable discovery in the field of lower cervical spine (LCS) reconstruction, as it has the advantages of both anterior and posterior approaches. In recent years, with in-depth research on ATPS fixation related to anatomy, biomechanical tests, and clinical applic...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang YW,Zeng T,Gao WC,Xiao X,Xiao Y,Chen X,Zhang SL,Deng L

更新日期：2019-08-21 00:00:00

abstract：:BACKGROUND Patients with diabetes mellitus (DM) commonly receive statins to suppress vulnerability to adverse cardiovascular events. It has been clinically proven that hepatotoxicity is one of the most severe adverse effects of statins. MATERIAL AND METHODS We constructed diabetic rat models by feeding rats with high-...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zeng H,Liu Z

更新日期：2019-08-17 00:00:00

abstract：:BACKGROUND Circular RNAs (circRNAs) are a kind of noncoding RNA with high cancer-specific expression, and great potential in regulating tumorigenesis. Among these, circRNA_100395 (circ_100395) has been reported to be downregulated in lung cancer, and participates in the process of tumor cell proliferation and metastas...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Chen Q,Chen Z,Cao S,Guo B,Chen Y,Feng Z,Wang J,Guo G,Chen X,Huang X

更新日期：2019-08-17 00:00:00

abstract：:BACKGROUND The aim of this study was to determine the effects of myeloma cells exposed to fluid shear stress on osteocytes and osteoclasts, and clarify the potential underlying mechanisms. MATERIAL AND METHODS A flow and a non-flow model were established using a flow fluid chamber. The myeloma cell line U266 and murin...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wang X,He Y,Tian S,Zhu F,Huang B,Zhang J,Chen Z,Wang H

更新日期：2019-08-10 00:00:00

abstract：:BACKGROUND The effect of foot orthoses in terms of kinematics and kinetics during walking could be affected on different geometrical designs. Therefore, the purpose of this study was to compare the biomechanical and clinical effects of 3 different insoles on rearfoot motion (RFM) and ankle joint moment parameters. MAT...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Han K,Bae K,Levine N,Yang J,Lee JS

更新日期：2019-08-08 00:00:00

abstract：:BACKGROUND Kidney injury is common in patients who have undergone cardiac surgery, and it has high morbidity and mortality. The objective of the study was to identify pre-, intra-, and post-operative risk factors responsible for kidney injury among patients who had undergone cardiac surgery. MATERIAL AND METHODS Patie...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Kang W,Wu X

更新日期：2019-08-06 00:00:00

abstract：:BACKGROUND Serine hydroxymethyltransferase 2 (SHMT2) is a key enzyme in one-carbon cell metabolism, including in liver cancer. However, the associations between SHMT2 expression at the gene and protein level and prognosis in patients with hepatocellular carcinoma (HCC) remains unknown. This study aimed to investigate ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Ji L,Tang Y,Pang X,Zhang Y

更新日期：2019-08-05 00:00:00

abstract：:BACKGROUND This study aimed to screen common and low-frequency variants of nonobstructive azoospermia (NOA)-associated genes, and to construct a database for NOA-associated single nucleotide variants (SNVs). MATERIAL AND METHODS Next-generation sequencing of 466 NOA-associated genes was performed in 34 patients with N...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu X,Xi Q,Li L,Wang Q,Jiang Y,Zhang H,Liu R,Wang R

更新日期：2019-08-04 00:00:00

abstract：:BACKGROUND Let-7 microRNAs (miRNAs) have the effects of inhibiting tumor growth and metastasis, however, the research in nasopharyngeal carcinoma (NPC) is limited. This study focused on the effects of Let-7 on NPC migration and invasion and the mechanism of action. MATERIAL AND METHODS Plasmid transfection was used to...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhao Z,Wen J,Peng L,Liu H

更新日期：2019-08-02 00:00:00

abstract：:BACKGROUND Different blood pressure targets should be formulated for different groups of people. This study aimed to assess the effectiveness of intensive blood control in improving the carotid morphology and hemodynamics in Chinese patients with hyperhomocysteinemia-type hypertension and high risk of stroke. MATERIAL...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wu W,Liu J,Li A,Li J,Yang Y,Ye X,Zheng J

更新日期：2019-08-01 00:00:00